Genesis 48:6

Jacob remembered Rachel (see 35:16–20) and blessed Joseph by making his two sons equal heirs with his other sons. The tribes of Ephraim and Manasseh would share equally with Jacob's other tribes (see Joshua 16–17). Jacob also gave Ephraim, Joseph’s younger son, the birthright (see 1 Chronicles 5:1–2). Because of this blessing, Ephraim and Manasseh became large and powerful tribes (see Joshua 17:14–18).

When Jacob blessed Ephraim and Manasseh, he showed faith in God's promise to continue. He understood that God's ways differ from human ways. From Jacob's long life, the writer of Hebrews chose the blessing of Joseph's sons as his greatest act of faith (Hebrews 11:21). Jacob followed God's will by giving the main blessing to the younger son instead of the older one, without any trickery or negative outcomes.

thy two sons, Ephraim and Manasseh--It was the intention of the aged patriarch to adopt Joseph's sons as his own, thus giving him a double portion. The reasons for this procedure are stated (Ch1 5:1-2).

are mine--Though their connections might have attached them to Egypt and opened to them brilliant prospects in the land of their nativity, they willingly accepted the adoption (Heb 11:25).

Here, I. Joseph, upon notice of his father's illness, goes to see him; though a man of honour and business, yet he will not fail to show this due respect to his aged father, Gen 48:1. Visiting the sick, to whom we lie under obligations, or may have opportunity of doing good, either for body or soul, is our duty. The sick bed is a proper place both for giving comfort and counsel to others and receiving instruction ourselves. Joseph took his two sons with him, that they might receive their dying grandfather's blessing, and that what they might see in him, and hear from him, might make an abiding impression upon them. Note, 1. It is good to acquaint young people that are coming into the world with the aged servants of God that are going out of it, whose dying testimony to the goodness of God, and the pleasantness of wisdom's ways, may be a great encouragement to the rising generation. Manasseh and Ephraim (I dare say) would never forget what passed at this time. 2. Pious parents are desirous of a blessing, not only for themselves, but for their children. "O that they may live before God!" Joseph had been, above all his brethren, kind to his father, and therefore had reason to expect particular favour from him.
II. Jacob, upon notice of his son's visit, prepared himself as well as he could to entertain him, Gen 48:2. He did what he could to rouse his spirits, and to stir up the gift that was in him; what little was lift of bodily strength he put forth to the utmost, and sat upon the bed. Note, It is very good for sick and aged people to be as lively and cheerful as they can, that they may not faint in the day of adversity. Strengthen thyself, as Jacob here, and God will strengthen thee; hearten thyself and help thyself, and God will help and hearten thee. Let the spirit sustain the infirmity.
III. In recompence to Joseph for all his attentions to him, he adopted his two sons. In this charter of adoption there is, 1. A particular recital of God's promise to him, to which this had reference: "God blessed me (Gen 48:3), and let that blessing be entailed upon them." God had promised him two things, a numerous issue, and Canaan for an inheritance (Gen 48:4); and Joseph's sons, pursuant hereunto, should each of them multiply into a tribe, and each of them have a distinct lot in Canaan, equal with Jacob's own sons. See how he blessed them by faith in that which God had said to him, Heb 11:21. Note, In all our prayers, both for ourselves and for our children, we ought to have a particular eye to, and remembrance of, God's promises to us. 2. An express reception of Joseph's sons into his family: "Thy sons are mine (Gen 48:5), not only my grandchildren, but as my own children." Though they were born in Egypt, and their father was then separated from his brethren, which might seem to have cut them off from the heritage of the Lord, yet Jacob takes them in, and owns them for visible church members. He explains this at Gen 48:16, Let my name be named upon them, and the name of my fathers; as if he had said, "Let them not succeed their father in his power and grandeur here in Egypt, but let them succeed me in the inheritance of the promise made to Abraham," which Jacob looked upon as much more valuable and honourable, and would have them to prize and covet accordingly. Thus the aged dying patriarch teaches these young persons, now that they were of age (being about twenty-one years old), not to look upon Egypt as their home, nor to incorporate themselves with the Egyptians, but to take their lot with the people of God, as Moses afterwards in the like temptation, Heb 11:24-26. And because it would be a piece of self-denial in them, who stood so fair for preferment in Egypt, to adhere to the despised Hebrews, to encourage them he constitutes each of them the head of a tribe. Note, Those are worthy of double honour who, through God's grace, break through the temptations of worldly wealth and preferment, to embrace religion in disgrace and poverty. Jacob will have Ephraim and Manasseh to believe that it is better to be low and in the church than high and out of it, to be called by the name of poor Jacob than to be called by the name of rich Joseph. 3. A proviso inserted concerning the children he might afterwards have; they should not be accounted heads of tribes, as Ephraim and Manasseh were, but should fall in with either the one or the other of their brethren, Gen 48:6. It does not appear that Joseph had any more children; however, it was Jacob's prudence to give this direction, for the preventing of contest and mismanagement. Note, In making settlements, it is good to take advice, and to provide for what may happen, while we cannot foresee what will happen. Our prudence must attend God's providence. 4. Mention is made of the death and burial of Rachel, Joseph's mother, and Jacob's best beloved wife (Gen 48:7), referring to that story, Gen 35:19. Note, (1.) When we come to die ourselves, it is good to call to mind the death of our dear relations and friends, that have gone before us, to make death and the grave the more familiar to us. See Num 27:13. Those that were to us as our own souls are dead and buried; and shall we think it much to follow them in the same path? (2.) The removal of dear relations from us is an affliction the remembrance of which cannot but abide with us a great while. Strong affections in the enjoyment cause long afflictions in the loss.

And now thy two sons. Jacob confers on his son the special privilege, that he, being one, should constitute two chiefs; that is, that his two sons should succeed to an equal right with their uncles, as if they had been heirs in the first degree. But what is this! that a decrepit old man assigns to his grandchildren, as a royal patrimony, a sixth part of the land in which he had entered as a stranger, and from which now again he is an exile! Who would not have said that he was dealing in fables? It is a common proverb, that no one can give what he has not. What, therefore, did it profit Joseph to be constituted, by an imaginary title, lord of that land, in which the donor of it was scarcely permitted to drink the very water he had dug for with great labour, and from which, at length, famine expelled him? But it hence appears with what firm faith the holy fathers relied upon the word of the Lord, seeing they chose rather to depend upon his lips, than to possess a fixed habitation in the land. Jacob is dying an exile in Egypt; and meanwhile, calls away the governor of Egypt from his dignity into exile, that he may be well and happy. Joseph, because he acknowledges his father as a prophet of God, who utters no inventions of his own, esteems as highly the dominion offered to him, which has never yet become apparent, as if it were already in his possession. Moreover, that Jacob commands the other sons of Joseph, (if there should be any,) to be reckoned in the families of these two brothers, is as if he directed them to be adopted by the two whom he adopts to himself.

And now thy two sons, Ephraim and Manasseh - are mine - I now adopt them into my own family, and they shall have their place among my twelve sons, and be treated in every respect as those, and have an equal interest in all the spiritual and temporal blessings of the covenant.

And thy issue, which thou begettest after them, shall be thine,.... The children of Joseph, that either were, or would be begotten after Ephraim and Manasseh; though whether ever any were is not certain; and this is only mentioned by way of supposition, as Jarchi interprets it, "if thou shouldest beget", &c. these should be reckoned his own, and not as Jacob's sons, but be considered as other grandchildren of Jacob's were, and not as Ephraim and Manasseh:

and shall be called after the name of their brethren in their inheritance; they should not have distinct names, or make distinct tribes, or have a distinct inheritance; but should be called either the children of Ephraim, or the children of Manasseh, and should be reckoned as belonging either to the one tribe, or the other, and have their inheritance in them, and with them, and not separate.

Shall be reputed as thy children, and my grandchildren, and shall not have any distinct share in my present or future inheritance, but shall have a part of their brethren’ s lot, in such manner and proportion as thou shalt think fit, or as their succeeding parents or governors shall determine. But it doth not appear, nor doth Scripture any where mention, that Joseph had any other sons but these, and therefore it is probable he had no more; only Jacob speaks this upon supposition, in case he should have any other.

Shall be called after the name of their brethren; either Ephraimites or Manassites.

Referring to the promise which the Almighty God had given him at Bethel (Gen 35:10. cf. Gen 38:13.), Israel said to Joseph (Gen 48:5): "And now thy two sons, which were born to thee in the land of Egypt, until (before) I came to thee into Egypt...let them be mine; Ephraim and Manasseh, like Reuben and Simeon (my first and second born), let them be mine." The promise which Jacob had received empowered the patriarch to adopt the sons of Joseph in the place of children. Since the Almighty God had promised him the increase of his seed into a multitude of peoples, and Canaan as an eternal possession to that seed, he could so incorporate into the number of his descendants the two sons of Joseph who were born in Egypt before his arrival, and therefore outside the range of his house, that they should receive an equal share in the promised inheritance with his own eldest sons. But this privilege was to be restricted to the two first-born sons of Joseph. "Thy descendants," he proceeds in Gen 48:6, "which thou hast begotten since them, shall be thine; by the name of their brethren shall they be called in their inheritance;" i.e., they shall not form tribes of their own with a separate inheritance, but shall be reckoned as belonging to Ephraim and Manasseh, and receive their possessions among these tribes, and in their inheritance. These other sons of Joseph are not mentioned anywhere; but their descendants are at any rate included in the families of Ephraim and Manasseh mentioned in Num 26:28-37; 1 Chron 7:14-29. By this adoption of his two eldest sons, Joseph was placed in the position of the first-born, so far as the inheritance was concerned (Ch1 5:2). Joseph's mother, who had died so early, was also honoured thereby. And this explains the allusion made by Jacob in Gen 48:7 to his beloved Rachel, the wife of his affections, and to her death-how she died by his side (עלי), on his return from Padan (for Padan-Aram, the only place in which it is so called, cf. Gen 25:20), without living to see her first-born exalted to the position of a saviour to the whole house of Israel.